Mature B-cell acute lymphoblastic leukaemia associated with a rare MLL-FOXO4 fusion gene.

The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.

The MLL gene from human chromosome 11q23 is involved in >30 different chromosomal translocations resulting in a plethora of different MLL fusion proteins. Each of these tends to associate with a specific leukaemia type, for example, MLL-AF9 is found mainly in acute myeloid leukaemia. We have studied the role of the Mll-AF9 gene fusion made in mouse embryonic stem cells by an homologous recombin...

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

MLL translocations in adult B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) are largely restricted to the immature CD10(-) immunophenotypes. MLL-AF4 is known to be the most frequent fusion transcript, but the exact frequencies of MLL aberrations in CD10(-) adult BCP-ALL are unknown. We present a genetic characterization of 184 BCR-ABL(-) CD10(-) adult ALL cases (156 cyIg(-), 28 cyIg(+...

Implication for how the single nucleotide polymorphism (SNP) of Fc receptor, Fc gamma RIIIa alters the interaction with anti-CD20 monoclonal antibody.

1. Armstrong SA, Staunton JE, Silverman LB, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genet. 2002;30:41-47. 2. McCabe NR, Kipiniak M, Kobayashi H, et al. DNA rearrangements and altered transcripts of the MLL gene in a human T-ALL cell line Karpas-45 with a t(X;11)(q13;q23) translocation. Genes Chromosom Cancer. 1994;9:221-2...

A model to investigate the oncogenic activity of MLL-fusions in Acute Myeloid Leukaemia

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